In 1945, Karl F. Keller founded the Hofer Konzertorchester (Hof Concert Orchestra), later renamed as Hofer Symphoniker (Hof Symphony Orchestra). Since its founding, the Hofer Symphoniker has developed into a cultural and education company with over 120 employees and see itself as a musical and social instrument fulfilling a cultural role in Hof and beyond. In 1965, Wilfried Anton assumed directorship of Hofer Symphoniker and is largely responsible for the reputation and success of the current symphony. In 1978, Hofer Symphoniker opened their own school of music, used to train future talents.Ithe is the musical centre of Upper Franconia region in the fields of orchestral and musical youth and adult education. As such, it is the only school of music in all of Germany that is attached to a professional symphony orchestra. In 1994 the new Hof Theatre (Theater Hof) was completed as the orchestra's home venue, where they perform concerts, operas and ballet. The theatre also serves as a multi-purpose venue for drama productions and other performances.
Honorary Conductor of the Hofer Symphoniker, since 2003, is the internationally known Enoch zu Guttenberg. He is actively involved in the artistic development of the orchestra, which is a great honour and highest award for the orchestra
Internationally renowned soloists such as Hilary Hahn, Baiba Skride or Claudio Bohórquez appear frequently with the Hofer Symphoniker. The Orchestra has given guest performances at the Gewandhaus in Leipzig on the opening of the Buchmesse, the Alte Oper Frankfurt, the Konzerthaus am Gendarmenmarkt in Berlin and at the Thurn and Taxis Festival in Regensburg. In addition, the Hofer Symphoniker appeared as a guest several times in the ZDF broadcast Götz Alsmanns Nachtmusik, as well as in the BR-show Weihnachten in Europa.